Photocatalytic α-arylation of cyclic ketones
WebPhotocatalytic α-arylation of cyclic ketones @article{Hossain2024PhotocatalyticO, title={Photocatalytic $\alpha$-arylation of cyclic ketones}, author={M. Selim Hossain and … WebJun 24, 2024 · 姓 名:易兵 职 称:教授 办公电话:0731-58683888 办公地点:新校区电气楼-307 电子邮件:[email protected]个人简介易兵,男,汉族,1970年生,湖南湘乡人,中共党员,博士,二级教授,博士生导师,湖南工程学院校长,校学术委员会主任。教育部大学化学课程教学指导委员会委员,湖南省普通高等学校 ...
Photocatalytic α-arylation of cyclic ketones
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WebThe direct α-arylation of unactivated carbonyl compounds using aryl halides represents a powerful method to synthesize criti-cal building blocks for diverse useful compounds. WebEnantioselective α-Arylation of Ketones via a Novel Cu(I)–Bis(phosphine) Dioxide Catalytic System. Journal of the American Chemical Society 2024, 143 (9) , 3289-3294.
WebThe direct α-arylation of carbonyl compounds using aryl halides represents a powerful method to synthesize critical building blocks for diverse useful compounds. Numerous … WebA combination of visible light photocatalysis and gold catalysis provides an entry into functionalized cyclic ketones from the coupling reaction of alkenyl and allenyl cycloalkanols with aryl diazonium salts via ring expansion-oxidative arylation. A mechanism involving generation of an electrophilic gold (III)-aryl intermediate is proposed.
WebMechanistic insights and a theoretical rationale that explains the ketone α-arylation versus dimerization selectivity are presented and moderate to good yields are obtained. An electrochemical procedure for the α-arylation of ketones has been developed. The method is based on the generation and one-pot anodic oxidation of silyl enol ethers in the … WebPhotocatalytic ɑ-Arylation of Cyclic Ketones Nature Synthesis February 3, 2024 The α-arylation of ketones is a powerful synthetic strategy for the construction of C–C bonds, but general...
WebAbstract. Nickel-catalyzed asymmetric α-heteroarylation of ketones with fluorinated heteroarenes is reported via C–F bond activation. A series of ketones and 2-fluoropyridine derivatives with different functional groups proceed well to provide the corresponding products containing all-carbon quaternary stereocenters in good yields (up to 99% yield) …
WebNov 15, 2013 · The direct β-coupling of cyclic ketones with aryl ketones has been achieved via the synergistic combination of photoredox catalysis and organocatalysis. Diaryl oxymethyl or aryl–alkyl oxymethyl rad... longworth building entranceWebApr 10, 2024 · Aryl chlorides serve as both cross-coupling partners and the chlorine radical source for the α-oxy C(sp3)-H arylation of cyclic and acyclic ethers. Mechanistic studies suggest that photolysis of a Ni(III) aryl chloride intermediate, generated by photoredox-mediated single-electron oxidn., leads to elimination of a chlorine radical in what amts ... longworth building directoryWebFeb 26, 2015 · Here we report the direct asymmetric amination of α-substituted cyclic ketones catalyzed by a chiral phosphoric acid, yielding products with a N-containing quaternary stereocenter in high yields and excellent enantioselectivities. longworth building servicesWebAug 20, 2024 · In addition to that, the mechanism of such radical photocatalytic systems remain not fully understood. ... as well as the α-arylation of carbonyl using cyclic ketones. The latter transformation exhibits the facile synthesis of α-arylated cyclic ketones as critical feedstock chemical for diverse useful molecules, especially in the biomedical ... longworth buildinghttp://fzx.hnie.edu.cn/info/1074/7640.htm longworth building dc addressWebJul 14, 2024 · Ketones serve as one of the most critical building blocks in organic synthesis, involving numerous functional group transformations. Herein, we report an unprecedented photoredox–nickel metallaphotoredox-catalyzed decarboxylative acylation of common aliphatic acids with readily available aromatic and aliphatic thioesters. hop-o\\u0027-my-thumb myWebThe photocatalytic reactions can be categorized into two types on the basis of appearance of the physical state of reactants. • Homogeneous photocatalysis: When both the … longworth building services limited