NettetJpn J Pharmacol. 2002 Jan;88 (1):69-76. The purpose of this study was to elucidate the molecular mechanism for renal tetracycline transport by human organic anion transporters (hOATs) using proximal tubular cells stably expressing hOATs. The cells stably expressing hOAT1, hOAT2, hOAT3 and hOAT4 exhibited a higher amount of [3H]tetracycline ... Nettet1. aug. 2012 · Human renal transporter (hOAT1, hOAT2, and hOCT2) inhibition assays characterize the inhibition potency of NCE and predict the potential for renal DDIs as a perpetrator with xenobiotics and drugs that are mainly renally cleared. In addition, ...
Transport mechanism and substrate specificity of human organic …
Nettet20. mai 2010 · Thủ tướng Chính phủ Phạm Minh Chính: ĐHQGHN truyền cảm hứng cùng khát vọng xây dựng đất nước hùng cường; Trường ĐH Khoa học Xã hội và Nhân văn tiên phong trong triển khai chữ ký số tới lãnh đạo Khoa/Viện/Trung tâm/Bộ môn Nettet1. jan. 2008 · These mycotoxins inhibited organic anion uptake mediated by hOAT1-4, and organic cation uptake mediated by hOCT1-2. By comparing the IC50 values of mycotoxins for hOATs, it was found that hOAT1 and hOAT3 exhibited higher affinity interactions with mycotoxins than hOAT2 and hOAT4. hour lift facelift
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NettetAbstract. Human organic anion transporter 2 (hOat2[SLC22A7]) is highly expressed in the human liver. Although localization, gene expression, substrate specificity and transport mechanisms of other human Oat isoforms such as human Oat1 (hOat1), human Oat3 (hOat3) and human Oat4 (hOat4) have been elucidated, information concerning human … Nettet1. mai 2005 · The human organic anion transporter 2 (hOAT2, SLC22A7 ) mediates the sodium-independent uptake of numerous drugs, including cephalosporins, salicylates, dicarboxylates, and prostaglandins, and is mainly expressed in hepatocytes. Because the regulation of hOAT2 expression is poorly understood, we characterized cis -acting … NettethOAT2 and S2 hOAT4 stained with polyclonal antibodies against hOAT2 and hOAT4, respectively, showed that the subcellular localization of hOAT2 and hOAT4 proteins was mainly on the cell membrane (A. Enomoto et al., un-published observation; E. Babu et al., unpublished observa-tion). Both the basolateral and apical portions of the mem- link rel stylesheet href css/index.css 是什么意思