Cub domain-containing protein

WebJun 1, 2008 · One such antigen, CUB domain-containing protein 1 (CDCP1), was recognized by monoclonal antibody 25A11 and is a single transmembrane molecule highly expressed in several metastatic cancers as well ... WebDec 31, 2012 · Cub domain containing protein 1 (CDCP1) is strongly expressed in tumors derived from lung, colon, ovary, or kidney. It is a membrane protein that is phosphorylated and then bound by Src family kinases. Although expression and phosphorylation of CDCP1 have been investigated in many tumor cell lines, the CDCP1 features responsible for …

Roles of CUB domain‐containing protein 1 signaling in cancer …

WebCUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and … WebCUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance, migration and matrix degradation during … earth dam design manual https://danielsalden.com

Roles of CUB domain‐containing protein 1 signaling in cancer …

WebMar 29, 2024 · CUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance, migration and matrix … WebLaw, M. E., Ferreira, R. B., Davis, B. J., Higgins, P. J., Kim, J.-S., Castellano, R. K., … Law, B. K. (2016). CUB domain-containing protein 1 and the epidermal ... WebMar 23, 2024 · The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two … ctfb austin tx

In vivo cleaved CDCP1 promotes early tumor dissemination via

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Cub domain-containing protein

Roles of CUB domain‐containing protein 1 signaling in cancer …

WebNing Zhao's 14 research works with 118 citations and 1,017 reads, including: Theranostic Targeting of CUB Domain–Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer WebOct 2, 2024 · Comment: annotation includes both PSPI/PSPII interaction residues highlighted. Download Cn3D for Viewing 3D Structure Scroll to Sequence Alignment …

Cub domain-containing protein

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WebMay 5, 2024 · We here demonstrate that the CUB-like-domain containing protein RBT-1 acts as a functional receptor of Cry6A, which mediates the intestinal cell interaction and … WebMay 21, 2024 · CUB domain-containing protein-1 (CDCP1) is a transmembrane protein that contains three extracellular CUB domains and acts as a substrate for Src family …

WebMar 2, 2015 · The transmembrane glycoprotein, CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein 1 (CDCP1) is overexpressed in several cancer types and is a predictor of poor prognosis for patients ... WebSummary. This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis.

WebSep 7, 2024 · The mature protein contains 2 putative CUB domains, a consensus type-1 palmitoylation motif, and 5 PxxP motifs that mediate binding to Src (190090) homology-3 domains. Northern blot analysis detected highest expression of a 6.0-kb transcript in skeletal muscle and colon, with lower expression in kidney, small intestine, placenta, and … WebDec 3, 2012 · Specific cleavage of the transmembrane molecule, CUB domain-containing protein-1 (CDCP1), by plasmin-like serine proteases induces outside–in signal transduction that facilitates early stages of ...

WebOct 3, 2024 · Abstract. Rationale: An antibody-drug conjugate (ADC) is a targeted therapy consisting of a cytotoxic payload that is linked to an antibody which targets a protein …

WebThe appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. In this review we describe synaptic proteins that contain the structural domains CUB, CCP, or TSP-1. These domains are found in … earth damWebCUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1/Trask is a 140kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two … ctf bool盲注WebAbstact. To measure the levels of serum CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in patients with ovarian cancer (OvCa), benign gynecological … earth dam design reportWebSep 1, 2009 · CUB and sushi domain-containing protein 3. Alternative names. CUB and sushi multiple domains protein 3; Gene names. Name. CSMD3. Synonyms. KIAA1894. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. Taxonomic lineage. earth dalstonWebNational Center for Biotechnology Information ctf bmp图片修复CUB domain is an evolutionarily conserved protein domain. The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated. These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guida… ctf blocksWebDec 9, 2010 · CDCP1 Is Up-Regulated in Highly Metastatic Melanoma Cell Lines. CDCP1, also known as SIMA135 or Trask, is a transmembrane glycoprotein that contains three putative extracellular CUB domains. CUB domains are believed to function in protein–protein ( 22, 23) and protein/carbohydrate ( 24) interactions. We initially … earth dam ppt